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在发育障碍中核应激和rDNA损伤的组织选择性影响

Eliezer Calo1,2, Bo Gu3, Margot E Bowen4

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Nature
|January 25, 2018
PubMed
概括

与核糖体生物生成缺陷相关的面疾病涉及DDX21功能障碍. 在头骨神经细胞中的DDX21功能受损会导致DNA损伤和亡,导致面部形.

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