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Updated: Feb 15, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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Published on: December 18, 2017

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Tet2通过mRNA氧化促进病原体感染诱导的骨髓形成

Qicong Shen1, Qian Zhang1,2, Yang Shi3

  • 1National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, China.

Nature
|January 25, 2018
PubMed
概括

通过减少mRNA中的5-甲基细胞素 (5-mC),Tet2促进感染诱导的骨髓形成,通过Adar1影响Socs3的表达. 这揭示了Tet2在哺乳动物免疫力中的新型表谱作用.

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