原生和适应性淋巴细胞顺序地塑造肠道微生物群和脂质代谢
Kairui Mao1, Antonio P Baptista1, Samira Tamoutounour2
1Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nature
|January 25, 2018
概括
天生的淋巴细胞 (ILC) 和T细胞顺序形成肠道微生物群. 当ILCs不受T细胞的控制时,通过IL-22信号破坏宿主脂质代谢.
科学领域:
- 免疫学
- 微生物组研究
- 代谢平衡
背景情况:
- 哺乳动物的肠道微生物群与其宿主有着互利的关系,微生物群成熟到平衡状态.
- 天生的淋巴细胞 (ILC) 和T细胞对于病原体控制至关重要,但它们在塑造成熟的肠道微生物群和维持平衡中的独特作用尚不清楚.
研究的目的:
- 研究先天性淋巴细胞 (ILC) 和T细胞在肠道微生物组发育和宿主代谢平衡中的顺序作用.
- 阐明ILC和T细胞影响肠道环境和宿主生理学的机制.
主要方法:
- 使用先进的多重定量成像来分析小鼠的细胞信号通路.
- 在肠道微生物成熟期间,将免疫缺陷小鼠 (缺乏CD4+T细胞) 与免疫能力强大的小鼠进行比较.
主要成果:
- 在没有CD4+T细胞的情况下,通过IL-23和IL-22诱导的3组ILC和肠上皮细胞中发现了持久的化STAT3特征.
- 在具有免疫能力的小鼠中观察到过渡性化STAT3激活,随着CD4+T细胞免疫的发展而减弱.
- 在T细胞缺乏的小鼠中,持续的IL-22产生通过降低脂质运输体表达来损害宿主脂质代谢.
结论:
- 在发育过程中,先天性和适应性淋巴细胞顺序运作,以建立肠道共存和代谢平衡.
- ILCs和T细胞之间的相互作用对调节肠道微生物群和宿主新陈代谢至关重要,具有影响脂质新陈代谢的独特作用.
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