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相关概念视频

Functional Classification of Joints01:09

Functional Classification of Joints

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Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

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长非编码RNA的功能分类和实验剖析

Florian Kopp1, Joshua T Mendell2

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|January 27, 2018
PubMed
概括

研究人员正在开发新的方法来了解长非编码RNAs (lncRNAs) 的功能,它们在基因组中很丰富. 这项工作旨在对lncRNA活动进行分类,以便更好地了解基因调节和疾病.

关键词:
在cRNA非编码RNA

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科学领域:

  • 基因组学
  • 分子生物学
  • 转录组学

背景情况:

  • 基因组被广泛转录,产生许多长非编码RNA (lncRNA).
  • 增强剂和促进剂等DNA调节元素启动双向转录.
  • 区分功能性lncRNA与庞大的转录组是一个重大挑战.

研究的目的:

  • 为分类和阐明 lncRNA 功能提供一个概念和实验框架.
  • 根据它们的调节机制 (cis 与 trans) 来分类 lncRNA 位点.
  • 提出剖析 lncRNA 活动的实验策略.

主要方法:

  • 目前的 lncRNA 研究和方法的审查.
  • 将 lncRNA 位点分为 cis 作用和 trans 作用.
  • 对分析 lncRNA 功能的实验方法的建议.

主要成果:

  • 基于其作用方式 (cis或trans) 的 lncRNA 位点的分类框架.
  • 建议实验策略来研究 lncRNA 的作用.
  • 突出这些策略的潜力,揭示新的生物学见解.

结论:

  • 了解 lncRNA 功能对于推进生理学和疾病知识至关重要.
  • 拟议的框架提供了对lncRNA研究的系统方法.
  • 进一步研究 lncRNA 的生物学有望有重大发现.