选择性合成二甲
Daniel W Terwilliger1, Dirk Trauner1,2
1Department of Chemistry, Ludwig-Maximilians University Munich , Butenandtstraße 5-13, 81377 Munich, Germany.
Journal of the American Chemical Society
|January 30, 2018
概括
研究人员合成了一种强效的抗菌药物 - - 纳夫托基安萨米. 这项研究证实了其结构,并证明了其复杂环系统的选择性生物模拟循环路径.
科学领域:
- 有机化学
- 医学化学
- 自然产品化学
背景情况:
- 迪维戈利德I是一种纳夫托基诺安萨米,具有广泛的抗菌特性.
- 它的复杂四环结构是通过环收缩从宏环前体产生的.
研究的目的:
- 为了实现分歧素I的融合和选择性合成.
- 确定二甲的绝对和相对配置.
- 调查拟议的生物模拟循环路径的选择性.
主要方法:
- 融合合成的战略.
- 选择性合成技术.
- 结构阐明 (NMR,MS,X射线结晶学 - 隐含).
- 生物模拟循环研究.
主要成果:
- 在不到20个线性步骤中成功合成了Divergolide I.
- 证实了迪维戈利德I的绝对和相对立体化学.
- 在原始divergolide前体的生物模拟循环中显示出高选择性.
结论:
- 一个实用的和高效的合成途径, 我被开发.
- 合成验证了涉及环收缩的拟议生物合成途径.
- 这项研究强调了天然产品合成中选择性仿生转化的潜力.
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