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Updated: Feb 15, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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PCSK9·LDLR相互作用的小分子抑制剂

Jaru Taechalertpaisarn1, Bosheng Zhao1, Xiaowen Liang2

  • 1Department of Chemistry , Texas A & M University , Box 30012, College Station , Texas 77842 , United States.

Journal of the American Chemical Society
|January 31, 2018
PubMed
概括

研究人员发现了针对PCSK9-LDLR相互作用的新型小分子,这是心脏病的主要途径. 通过破坏这种关键的蛋白质-蛋白质结合, 这些化合物显示出开发新疗法的潜力.

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