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Updated: Feb 15, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
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突破 Alu 双重 RNA 的自我耐受性 导致 MDA5 介导的炎症

Sadeem Ahmad1, Xin Mu1, Fei Yang1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Cell
|February 4, 2018
PubMed
概括

MDA5受体的异常激活会导致像艾卡迪-古提耶氏综合征 (AGS) 这样的免疫疾病,这是由于Alu反元素的细胞dSRNA. 这些自我dsRNAs被MDA5的AGS变体识别,导致免疫系统的失调.

关键词:
艾卡迪-古蒂埃尔综合征其他IFIH1 其他其他国家自动炎症天生的免疫力复制元件

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