通过计算引导的基质加法/循环/碎片级联合成 (-) - 染色体B
Daniel J Tao1, Yuriy Slutskyy1, Mikko Muuronen1
1Department of Chemistry, University of California , Irvine, California 92697-2025, United States.
Journal of the American Chemical Society
|February 8, 2018
概括
研究人员首次完全合成了海洋二氧化, 一种新的激素级联反应有效地构建了该分子,使用可见光光催化剂在一个步骤中形成多个立体中心.
科学领域:
- 有机化学
- 自然产品合成
- 光催化
背景情况:
- 海洋二类物质,如染色体,是具有潜在生物活性的复杂自然产物.
- 开发有效的合成途径对这些分子的进一步研究和潜在应用至关重要.
- 具有多个连续立体中心的分子的立体选择合成仍然是有机化学的一个重大挑战.
研究的目的:
- 实现第一个 (-) - 染色体 B 的综合合成,
- 开发一种新的合成策略, 采用双分子激素级联反应.
- 研究可见光光催化剂的使用,以启动关键的C-C键形成步骤.
主要方法:
- 设计了一种新的双分子激素添加/循环/碎片级联反应来构建二基核.
- 使用或二催化剂的可见光光催化,通过氧化还原活性的碎片化启动了级联.
- 两个复杂片段的等分量在一个合成步骤中被合在一起.
- 用计算研究来指导反应的发展和理解立体选择性.
主要成果:
- 首次成功合成 (-) - 染色体B.
- 关键级联反应在一个步骤中形成了两个C-C键和四个连续的立体中心.
- 这种光催化分解方法被证明是有效的,使两种复杂的碎片能够结合起来.
- 计算模型为反应的立体化学结果提供了洞察力.
结论:
- 已确定一种高效且立体选择性的 (-) - 染色体B的途径.
- 开发的激应级反应代表了构建复杂分子架构的强大新方法.
- 可见光光催化为启动具有挑战性的合成转化提供了可持续和有效的策略.
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