后壁皮层代表感官历史,并调解其对行为的影响
Athena Akrami1,2,3, Charles D Kopec1,2, Mathew E Diamond4
1Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA.
Nature
|February 8, 2018
概括
后壁皮质 (PPC) 对于处理先前的感官信息至关重要,而不是工作记忆本身. 通过减少过去刺激对当前决策的影响,
科学领域:
- 神经科学
- 认知科学
- 计算神经科学
背景情况:
- 之前的刺激统计显著影响工作记忆和感知.
- 之前感官体验的使用背后的神经机制在很大程度上是未知的.
研究的目的:
- 确定负责表示和利用先前刺激信息的神经区域.
- 研究后壁皮质在处理感官史中的作用.
主要方法:
- 鼠被训练进行听觉参数工作记忆任务.
- 用PPC的光遗传沉默来评估其因果作用.
- 进行了电生理记录以分析神经活动.
主要成果:
- 通过减少先前感官刺激的影响, 制PPC出乎意料地提高了性能.
- PPC神经元显示了比目前的试验更多关于以前的试验的信息.
- 在PPC对刺激史和行为影响的表现之间发现了相关性.
结论:
- 对于处理感官刺激史而不是工作记忆功能而言,
- 通过利用先前的信息, PPC 提供了研究感知和记忆的新途径.
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