催化的酸化:一般性和机制
Tieqiao Chen1,2, Chang-Qiu Zhao3,2, Li-Biao Han2
1College of Material and Chemical Engineering, Hainan University , Haikou, Hainan 570228, China.
Journal of the American Chemical Society
|February 9, 2018
概括
这项研究探讨了使用各种P(O) -H化合物的催化化. 它详细介绍了马尔科夫尼科夫形成的催化剂性能,基质范围和反应机制.
科学领域:
- 有机金属化学
- 催化剂
- 化学
背景情况:
- 酸盐的化是有机化学中的关键反应.
- 催化为CP键形成提供了有效的途径.
- 了解基质范围和反应机制对于合成应用至关重要.
研究的目的:
- 综合研究催化与多种P (O) -H化合物的酸化.
- 确定这种转变的普遍性,范围,局限性和机制性途径.
- 确定选择性马尔科夫尼科夫合成的最佳催化系统.
主要方法:
- 催化剂 (例如,Pd/dppp,Pd/dppe,Pd(PPh3) 4) 和配体的选.
- 测试各种各样的有机组的芳香和有机基.
- 对包括H-酸盐,H-酸盐,二次氧化物和低酸在内的不同P(O) -H化合物的研究.
- 涉及中间隔离和表征的机制研究.
主要成果:
- Pd/dppp在H-酸盐酸化方面表现出高效率,产生来自各种基的马尔科夫尼科夫添加物.
- 对于H-酸盐和二次氧化物,Pd/dppe/Ph2P(O) OH被证明是有效的,提供具有高区域选择性的马尔科夫尼科夫产品.
- Pd(PPh3) 4催化了对终端酸的添加,形成了马尔科夫尼科夫酸.
- 在这些条件下发现酸,酸及其单无反应性.
结论:
- 该研究确定了催化化对各种P (O) -H化合物和的有用性和局限性.
- 机理性洞察揭示了不同P(O) -H基质的独特途径,突出了水化和配体交换的作用.
- 这些发现为获取功能化有机化合物提供了强大的合成方法.
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