在动作启动前的多巴胺神经元活动,并激发未来的运动
Joaquim Alves da Silva1,2, Fatuel Tecuapetla1,3, Vitor Paixão1
1Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Nature
|February 9, 2018
概括
在运动开始之前,黑色物质 (SNc) 中的多巴胺神经元 (DAN) 暂时激活,影响运动活力. 抑制或激活这些DAN直接影响运动概率和活力, 这对生存至关重要.
科学领域:
- 神经科学
- 发动机控制
- 帕金森病的研究
背景情况:
- 黑色质中多巴胺神经元 (DANs) 对于运动至关重要,它们的丧失与帕金森病有关.
- 之前的模型将DAN在自律运动中的作用归因于增强活性,而相变则与奖励预测有关.
研究的目的:
- 调查自发运动开始前短暂多巴胺神经元活动的必要性和具体作用.
- 区分多巴胺活动对运动启动和持续运动的影响.
主要方法:
- 记录了小鼠在自动运动任务中的Snc DANs活动.
- 在不运动期间抑制和激活特定的DAN群体.
- 对运动启动,概率和活力的观察效应.
主要成果:
- 在自我节奏运动开始之前,SNc DANs的一个子集显示过渡性活动增加,独立于奖励.
- 这种运动前的DAN活动与未来的运动活力相关.
- 抑制DAN降低了运动概率和活力;激活它们增加了这些参数.
- 移动开始后的操作没有影响正在进行的移动.
结论:
- 在运动开始前的SNc DAN活动会对未来运动的概率和活力产生影响.
- 这一发现涉及DAN在启动自发和学习的行为,与其在奖励处理或持续运动控制中的作用不同.
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