陆地行走的神经基质的古老起源
Heekyung Jung1, Myungin Baek1, Kristen P D'Elia1
1Neuroscience Institute, Department of Neuroscience and Physiology, NYU School of Medicine, New York, NY 10016, USA.
Cell
|February 10, 2018
概括
神经回路对于行走,对于脊椎动物的四肢控制至关重要,起源于古代鱼类. 这些电路存在于小滑板上, 显示保存的基因程序在四足动物进化之前.
科学领域:
- 进化生物学
- 神经科学
- 发育生物学
背景情况:
- 走路是陆地脊椎动物的主要运动方式.
- 控制行走的神经回路的进化起源尚不清楚.
- 一些鱼类表现出类似行走的行为,
研究的目的:
- 调查原始海洋脊椎动物中行走的神经基质的存在.
- 在脊椎动物进化过程中, 确定关键的神经回路的出现时间.
主要方法:
- 研究了小滑板 (Leucoraja erinacea), 一种大约4亿两千万年前从四足动物分离出来的物种.
- 分析了四足动物的骨盆翅膀运动特征,
- 检查了保存的霍克斯转录因子依赖的基因程序,
主要成果:
- 小滑板显示了四足动物运动的核心特征.
- 在滑冰鞋中存在一个保存的Hox基因网络,对选择性/肢体肌肉内化至关重要.
- 这种基因网络与基于轴向肌肉的游泳回路不同,在许多现代鱼类中似乎减少了.
结论:
- 步行的神经回路是从脊椎动物配对的基因调节网络进化而来的.
- 这些发现表明,行走的基本神经架构早于陆地转型.
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