快速增长的内神经元为有效的学习提供突破性控制,和可塑性
Scott F Owen1, Joshua D Berke2, Anatol C Kreitzer3
1Gladstone Institutes, San Francisco, CA 94158, USA.
Cell
|February 10, 2018
概括
快速激增的神经元 (FSI) 通过调节中等棘状神经元 (MSN) 爆发和流入来控制神经网络活动. 这种调节对于纹状体的序列学习和突触可塑性至关重要.
科学领域:
- 神经科学
- 细胞神经科学
- 系统神经科学
背景情况:
- 快速激增的神经元 (FSI) 是前脑中关键的GABAergic细胞,参与网络增益控制和可塑性.
- 在增益控制和可塑性中FSI角色之间的相互作用仍然不太清楚.
- 研究FSI如何影响中等脊状投射神经元 (MSN) 对于理解条状神经元功能至关重要.
研究的目的:
- 阐明一个统一的机制,通过该机制,状FSI控制MSN活动和突触可塑性.
- 确定FSI在运动序列学习和条形依赖策略中的作用.
主要方法:
- 细胞类型特异性FSI的切除.
- 在体内光遗传学和电生理学.
- 在运动序列任务中进行成像和行为分析.
主要成果:
- 在体内,FSI静音增加了MSN爆发,过渡物和AMPA/NMDA比率.
- FSI静音增加了的短暂频率,但降低了它们的任务-事件特异性.
- FSI消去影响了依赖于条状体的自我中心学习策略的获得.
结论:
- 体FSI使用前进抑制来暂时限制MSN破裂和依赖的可塑性.
- 这种FSI介导的控制对于促进条状体依赖的序列学习至关重要.
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