NK细胞刺激cDC1进入瘤微环境促进癌症免疫控制

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Jan P Böttcher1, Eduardo Bonavita2, Probir Chakravarty3

  • 1Immunobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Cell
|February 13, 2018
PubMed
概括

自然杀手 (NK) 细胞通过化学因子招募常规的1型树突细胞 (cDC1). 瘤产生的前列腺素E2 (PGE2) 破坏了这一关键的NK细胞cDC1轴,阻碍了抗癌反应.

关键词:
癌症免疫疗法树突细胞免疫逃避瘤免疫控制瘤微环境

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