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Updated: Feb 14, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
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通过对KSR蛋白的异质控制,MEK驱动BRAF激活

Hugo Lavoie1, Malha Sahmi1, Pierre Maisonneuve2

  • 1Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal, Québec H3C 3J7, Canada.

Nature
|February 13, 2018
PubMed
概括

RAF激酶在癌症中至关重要, 但它们的二元化阻碍了药物开发. 这项研究揭示了BRAF和KSR1之间的新相互作用,揭示了RAF激酶激活和挑战KSR的新机制.

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