在心脏停止和神经残疾后早期高氧暴露之间的关联:前性多中心协议指导的队列研究
Brian W Roberts1, J Hope Kilgannon1, Benton R Hunter2
1Department of Emergency Medicine (B.W.R., J.H.K., S.T.).
Circulation
|February 14, 2018
概括
在心脏骤停后早期接触高氧水平与更糟糕的神经结果有关. 这项研究发现高氧度 (Pao2> 300 mm Hg) 与医院出院时的神经功能差异独立相关.
科学领域:
- 心脏病学
- 神经学
- 危急护理医学
背景情况:
- 对于心脏骤停后的高氧暴露和患者的结果存在矛盾.
- 早期的复苏后氧化被假定会对神经恢复产生负面影响.
研究的目的:
- 测试早期复苏后高氧化与神经结果不佳的假设.
- 研究心脏骤停后不同水平的高氧和神经功能之间的关联.
主要方法:
- 在成人心脏骤停患者中进行多中心前性队列研究.
- 被定义为在自发循环恢复后6小时内动脉氧气的部分压力 (Pao2) > 300 mm Hg.
- 在医院出院时使用修改的兰金尺度评分评估神经学结果差;使用多变量回归分析.
主要成果:
- 在280名患者中,有38%的患者出现过氧症;有77%的患者出现了不良的神经结果,而没有出现过氧症的患者则为65%.
- 过氧与神经功能低下独立相关 (RR 1. 23).
- 每增加一小时的高氧化剂增加了3%的神经结果不良的风险 (RR1. 03).
结论:
- 在心脏骤停后的早期高氧暴露与神经功能不良独立相关.
- 在Pao2水平为300mmHg及以上时,观察到高氧和神经不良结果之间的关联.
相关概念视频
Genome-wide Association Studies-GWAS
15.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.8K
Intellectual Disability
796
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
796
Learning Disabilities
639
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
Dyslexia
Dyslexia is a...
639
Cardiopulmonary Resuscitation I: Adult
777
Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
777
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
934
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
934
Associative Learning
1.5K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.5K


