Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Synapse02:47

The Synapse

133.8K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
133.8K
Electrical Synapses01:28

Electrical Synapses

11.0K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
11.0K
Chemical Synapses01:26

Chemical Synapses

12.0K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.0K
Chemical Synapses01:26

Chemical Synapses

4.6K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
4.6K
Overview of Synapses01:25

Overview of Synapses

5.6K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
5.6K
Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Neural circuits for valence updating in social memory.

Science (New York, N.Y.)·2026
Same author

FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery.

Drug delivery·2026
Same author

Dopamine in the Nucleus Accumbens Signals Salience of Auditory Deviance.

The European journal of neuroscience·2026
Same author

Clinical and prognostic insights into Trousseau's syndrome in gynecologic malignancies: a multicenter study.

Journal of gynecologic oncology·2026
Same author

Safety and oncologic outcomes of total laparoscopic versus abdominal hysterectomy following diagnostic conization for adenocarcinoma in situ and stage IA1 cervical cancer: a multicenter retrospective study.

International journal of clinical oncology·2026
Same author

Contribution of laparoscopic surgery to the diagnosis of ovarian metastasis from thymoma: A rare case and review of the literature.

Gynecologic oncology reports·2025

相关实验视频

Updated: Feb 14, 2026

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

18.1K

河马可以降低突触的调节

Hiroaki Norimoto1,2, Kenichi Makino1, Mengxuan Gao1

  • 1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

Science (New York, N.Y.)
|February 14, 2018
PubMed
概括

通过减少不相关活动, 提升记忆力. 在睡眠期间阻断这些波纹会损害记忆形成和突触重量调节.

更多相关视频

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
18:11

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

Published on: November 16, 2010

36.7K
Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

11.9K

相关实验视频

Last Updated: Feb 14, 2026

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

18.1K
Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
18:11

Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number

Published on: November 16, 2010

36.7K
Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

11.9K

科学领域:

  • 神经科学
  • 睡眠科学
  • 突触可塑性

背景情况:

  • 睡眠在调节突触可塑性和记忆巩固中的确切作用尚未完全理解.
  • 在睡眠期间的神经活动,特别是波波,被假定会影响突触变化.

研究的目的:

  • 研究海马突波波在睡眠中的突触可塑性中的因果作用.
  • 确定波对记忆巩固和突触重量调节的影响.

主要方法:

  • 使用小鼠模型记录和操纵慢波睡眠状态中的海马尖波.
  • 采用技术使尖的波浪沉默,并评估对突触可塑性和记忆的后续影响.
  • 研究了N-甲基-d-酸盐受体在观察到的突触下调中的参与.

主要成果:

  • 鉴定出海马突波是长期突触抑郁的内在触发因素.
  • 在睡眠期间抑制尖的波浪, 阻止了突触重量的自然下调.
  • 导致学习障碍和记忆巩固.
  • 突触下调取决于N- 甲基- d- 酸盐受体的激活,并且特定于某些输入通路.

结论:

  • 通过在睡眠期间削弱无关的神经连接,
  • 这些发现揭示了波在调节突触可塑性和记忆中的新功能.
  • 结果支持睡眠能积极改变突触强度以优化记忆存储的假设.