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Updated: Feb 14, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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激活NMDA类型的谷氨酸受体促进血管重塑和肺动脉高血压

Sébastien J Dumas1,2, Gilles Bru-Mercier1,2, Audrey Courboulin1,2

  • 1INSERM UMR-S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France (S.J.D., G.B.-M., A.C., M.Q., C.R.-M, F.A., M.K.N., B.R., E.G., M.-C.V., M.V., N.R., P.D., E.F., F.P., M.H., S.C.-K.).

Circulation
|February 16, 2018
PubMed
概括

肺动脉高血压 (PAH) 涉及由代谢变化驱动的血管重塑. 这项研究揭示了谷氨酸-N-甲基-D-酸盐受体 (NMDAR) 轴在PAH中失调,这表明NMDARs是抗重塑治疗的潜在治疗标.

关键词:
这种NMDA受体是NMDA受体.末端蛋白-1-1的使用.谷氨酸酸盐的使用方法来自血小板的生长因子.肺动脉高血压 肺动脉高血压顺肌细胞是平滑肌肉细胞.血管改造 血管改造 血管改造

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