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关联CRISPR-Cas12a目标释放无差别的单链DNase活动

Janice S Chen1, Enbo Ma1, Lucas B Harrington1

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|February 17, 2018
PubMed
概括

除了基因组编辑之外,CRISPR-Cas12a酶还具有新的单链DNA (ssDNA) 分裂活性. 这一发现导致了DETECTR的开发,用于高度敏感的DNA检测.

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