循环时钟神经元不断监测环境温度以设定睡眠时间
Swathi Yadlapalli1, Chang Jiang2, Andrew Bahle1
1Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nature
|February 22, 2018
概括
果
科学领域:
- 神经科学
- 时间生物学
- 感官生物学
背景情况:
- 循环时钟调节行为和生理上的日常节奏.
- 环境温度周期会影响人类的睡眠模式, 但神经机制尚不清楚.
- 时钟神经元整合光线和温度线索, 但温度的作用较少被理解.
研究的目的:
- 研究Drosophila melanogaster中昼夜钟神经元如何处理环境温度的变化.
- 确定温度影响昼夜节律的神经通路和机制.
- 了解温度感应对睡眠和清醒周期的作用.
主要方法:
- 在Drosophila钟神经元的体内成像.
- 热传感途径的基因操纵.
- 在自然温度周期下对睡眠模式的行为分析.
主要成果:
- 后背神经元1 (DN1p) 是促进睡眠的时钟神经元的一个子集,监测环境温度.
- DN1p神经元通过升温被抑制,而通过降温被激发,独立于光线线索.
- 来自带器官和带的热传感输入对DN1p功能至关重要.
- DN1p神经元及其热传感输入对于正常的睡眠时间和温度周期至关重要.
结论:
- 在昼夜神经网络中,DN1p神经元是温度信息的关键传感通道.
- 昼夜系统积极整合环境温度以协调睡眠和活动时间.
- 这项研究揭示了基于温度的昼夜调节影响睡眠行为的新机制.
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