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Updated: Feb 14, 2026

Improving the Accuracy of Flow Cytometric Assessment of Mitochondrial Membrane Potential in Hematopoietic Stem and Progenitor Cells Through the Inhibition of Efflux Pumps
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在亡过程中,BAK/BAX巨孔促进线粒体和mtDNA流出

Kate McArthur1,2,3, Lachlan W Whitehead4,2, John M Heddleston5

  • 1Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. kate.mcarthur@monash.edu benjamin.kile@monash.edu.

Science (New York, N.Y.)
|February 24, 2018
PubMed
概括

死亡的细胞释放线粒体DNA (mtDNA),通过cGAS/STING通路触发天生的免疫力. BAK/BAX孔允许内线粒体膜,暴露mtDNA并激活I型干扰素信号.

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