骨髓母细胞瘤瘤转移的血液路径
Livia Garzia1, Noriyuki Kijima1, A Sorana Morrissy1
1Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.
Cell
|February 24, 2018
概括
骨髓母细胞瘤癌细胞可以通过血液传播,形成瘤转移. 向化学基因CCL2可能为诊断和治疗髓母细胞瘤扩散提供新的途径.
科学领域:
- 癌症学
- 神经科学
- 癌症转移研究
背景情况:
- 骨髓母细胞瘤的死亡率主要是由于转移性疾病,但由于缺乏转移性样本,研究受到限制.
- 骨髓母细胞瘤转移主要发生在脑膜表面,这表明脑脊液扩散.
- 目前对脑髓母细胞瘤扩散的了解尚不完整,这阻碍了有效的治疗策略.
研究的目的:
- 调查脑髓母细胞中循环瘤细胞的存在和作用.
- 为了确定脑髓母细胞瘤CTC是否可以通过血液传播,形成瘤转移.
- 确定驱动膜传播的分子机制,特别是CCL2的作用.
主要方法:
- 在未经治疗的患者中检测脑髓母细胞瘤循环瘤细胞 (CTC).
- 在体内研究使用侧翼外移植和副生态模型进行血液传播.
- 在脑髓母细胞瘤瘤转移中分析化学基因CCL2表达.
主要成果:
- 在未经治疗的患者中发现脑髓母细胞瘤CTC.
- 在体内证明骨髓母细胞瘤CTC通过血液扩散以形成瘤转移.
- 在乳腺内转移中CCL2的高表达,CCL2足以驱动传播.
结论:
- 骨髓母细胞瘤可以通过循环的瘤细胞进行血液传播.
- 瘤转移是由CCL2表达驱动的.
- 血液传播为脑髓母细胞瘤提供了新的诊断和治疗点.
相关概念视频
Routes of Persuasion
68.8K
Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?
68.8K
Routes of Drug Administration: Parenteral
3.0K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
3.0K
Routes of Drug Administration: Overview
9.7K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
9.7K
Drug Delivery: Enteral Route
1.9K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.9K
Drug Delivery: Parenteral Route
1.8K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.8K
Additional Routes of Drug Administration
5.0K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
5.0K


