具有可追溯协同疗法的增强药物负载和反应性氧物种响应释放能力的正电荷多药物两性体
Yan Li1, Yanhui Li1, Weihong Ji1,2
1State Key Laboratory of Biochemical Engineering , Institute of Process Engineering, Chinese Academy of Sciences , Beijing 100190 , China.
Journal of the American Chemical Society
|February 28, 2018
概括
研究人员开发了用于阿尔茨海默病 (AD) 治疗的新型可追溯纳米粒子. 这些纳米粒子提供药物和神经干细胞, 改善记忆缺陷, 实现MRI追踪.
科学领域:
- 生物医学工程
- 纳米技术
- 神经科学
背景情况:
- 由于不同的化学性质,不同疗法 (药物,核酸,纳米颗粒) 的同时输送具有挑战性.
- 现有的载体难以有效地联合封装疏水性和疏水性剂.
- 在神经退行性疾病中开发可追溯的协同疗法仍然是一个重大障碍.
研究的目的:
- 合成带正电荷的多种药物两性分子,以制造可追溯的共递纳米粒子 (NP).
- 通过同时提供药物和神经干细胞 (NSCs) 来实现阿尔茨海默病 (AD) 的协同治疗.
- 使用超偏磁氧化铁纳米立方体 (SPION) 进行磁共振成像 (MRI) 追踪移植的NSC.
主要方法:
- 合成带正电荷的多种药物.
- 在NP中加载疏水性SPION和let-7b反意义寡核酸.
- 在体外评估药物释放和对神经干细胞 (NSC) 的影响.
- 在2xTg-AD小鼠模型和MRI追踪中对NP疗效的体内评估.
主要成果:
- 成功构建可追溯的NP能够同时提供SPION,药物和let-7b反意义寡核酸.
- NPs显示药物释放受控,NSC分化减少,BDNF分泌增强.
- 在2xTg-AD小鼠中,使用NP显著挽救记忆缺陷.
- 在NP中的SPION允许对NSC移植部位和迁移进行MRI跟踪.
结论:
- 具有正电荷的多药基可追溯NP为阿尔茨海默病治疗提供了一个有希望的平台.
- 这种方法有助于协同治疗和实时监测治疗干预.
- 开发的NP具有治疗阿尔茨海默氏症和其他神经退行性疾病的潜力.
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