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需要通过C型乳素受体识别DHN- 黑色素,才能对阿斯伯吉勒斯产生免疫力

Mark H T Stappers¹, Alexandra E Clark¹, Vishukumar Aimanianda²

¹Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK.

|March 1, 2018

概括

研究人员发现了MelLec,一种C型乳素受体,对抗真菌免疫至关重要. 在小鼠和人类中,MelLec识别了真菌的黑色素,增强了对像Aspergillus fumigatus这样的感染的保护.

科学领域:

免疫学
菌群学
分子生物学

背景情况:

模式识别受体对于检测微生物入侵和启动免疫反应至关重要.
C型讲蛋白是抗真菌免疫的关键参与者,可识别真菌细胞壁的碳水化合物.
作为免疫活性联体的真菌黑色素的识别机制仍未确定.

研究的目的:

识别负责识别真菌黑色素的受体.
阐明这种受体在抗真菌免疫中的作用.
研究该受体在人类真菌感染中的临床相关性.

主要方法:

一种新型C型莱克受体MelLec的鉴定和表征.
分析MelLec对真菌黑色素的结合特异性
在小鼠和人类细胞中分析MelLec的表达.
在传播真菌感染的小鼠模型中评估MelLec的作用.
对人类MelLec单核酸多态性及其与感染易感性的研究.

主要成果:

鉴定出MelLec是一种C型莱克受体,可识别1,8-二氧纳 (DHN) - 黑色素的纳二醇单元.
MelLec 在 Aspergillus fumigatus 状子和其他 DHN 菌上识别出黑色素.
通过小鼠的内皮细胞 (肺和肝) 和人类的骨髓细胞来表达MelLec.
在小鼠模型中,MelLec对传播的A. fumigatus感染的保护至关重要.
人类MelLec单核酸多态性损害了骨髓炎炎症反应,增加了干细胞移植患者对侵袭性阿斯伯吉勒斯感染的易感性.

结论:

MelLec是一种新型受体,可识别的DHN- 黑色素,这是一个保存的成分.
在小鼠和人类的抗真菌免疫中,MelLec起着至关重要的作用.
在侵袭性真菌感染中,MelLec是潜在的治疗点.

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