在塑造人类肠道微生物群方面,环境占主体基因的优势
Daphna Rothschild1,2, Omer Weissbrod1,2, Elad Barkan1,2
1Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Nature
|March 1, 2018
概括
宿主基因在塑造人类肠道微生物群中起到很小的作用. 饮食和家庭接触等环境因素更有影响力,表明微生物组疗法可以使不同的人群受益.
科学领域:
- 人类微生物组研究
- 遗传学与宿主微生物的相互作用
背景情况:
- 了解影响人类肠道微生物组合的因素至关重要.
- 主体遗传对微生物群多样性的确切贡献尚不清楚.
研究的目的:
- 研究宿主遗传,祖先和肠道微生物组合之间的关联.
- 确定驱动微生物群变化的关键环境因素.
- 评估微生物组数据对预测人类特征的影响.
主要方法:
- 对1046名健康个体的基因型和微生物组数据的分析.
- 不同的遗传祖先和家庭接触者的微生物组合的比较.
- 统计建模与饮食,药物和人体测量相关的微生物组变异性.
主要成果:
- 肠道微生物组组成与遗传血统没有显著关联.
- 宿主基因对微生物组合有很小的影响.
- 在基因不相关的家庭成员中观察到显著的微生物组相似性.
- 饮食,药物和人体测量解释了超过20%的微生物群变异性.
- 微生物组数据提高了葡萄糖水平和肥胖等特征的预测准确性.
结论:
- 环境因素,特别是饮食和家庭共享,是肠道微生物组合的强大决定因素,而不是宿主遗传或祖先.
- 微生物组分析可以提高宿主特征的预测能力,超越了传统的遗传和环境数据.
- 针对微生物组的干预措施对改善临床结果的多样化遗传背景有希望.
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