一个动态的Oligourea折叠器中的竞争性键极性:一个分子弹扭矩平衡
Romina Wechsel1, Matej Žabka1, John W Ward1
1School of Chemistry , University of Bristol , Cantock's Close , Bristol BS8 1TS , United Kingdom.
Journal of the American Chemical Society
|March 2, 2018
概括
基于终端组结合,基聚合物在两个基之间动态切换. 阳离子客体触发了结构转换, 证明了折叠体是分子扭矩平衡.
科学领域:
- 超分子化学
- 有机化学
- 聚合物科学
背景情况:
- 折叠分子是模仿生物聚合物的合成寡合物.
- 控制折叠分子构造对于设计功能分子至关重要.
研究的目的:
- 合成具有可调节终端组的对称橄氨酸折叠体.
- 研究这些折叠体的构造性行为和结合性.
主要方法:
- 使用中环素-1,2-胺合成酸盐折叠体
- 使用光谱技术进行折叠形状的表征.
- 在溶液中研究折叠剂-客体相互作用.
主要成果:
- 折叠体存在于两个螺丝感合体的动态平衡中.
- 终端组的结能力决定了形状偏好.
- 阴性客体通过重组分子内键网络来诱导构造转换.
结论:
- 橄素折叠体作为分子扭力平衡剂.
- 它们的形状偏好是由相互竞争的键配对决定的.
- 折叠器可以设计为特定的分子识别事件.
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