针对急性上下呼吸道感染的抗生素治疗,进行前素测试
Philipp Schuetz1,2, Yannick Wirz1, Beat Mueller1,2
1Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland.
JAMA
|March 7, 2018
概括
甲基素检测有助于医生决定是否使用抗生素治疗呼吸道感染. 这种方法减少了抗生素暴露,副作用和患者死亡率.
科学领域:
- 传染性疾病
- 临床微生物学
- 危急护理医学
背景情况:
- 抗生素耐药性是一个日益增长的全球健康威胁.
- 上下呼吸道感染是处方抗生素的常见原因.
- 生物标志物可以帮助区分细菌和病毒感染,以优化抗生素管理.
研究的目的:
- 评估普卡尔西在治疗急性呼吸道感染的抗生素治疗中的临床效用.
- 为了比较治疗过程中的患者的临床结果与标准治疗.
主要方法:
- 随机对照试验的系统审查和元分析.
- 包括各种急性呼吸道感染 (如肺炎,支气管炎) 的患者.
- 评估抗生素暴露,不良事件和死亡率作为主要结局.
主要成果:
- 甲素指导与显著较低的抗生素处方率有关.
- 较少的抗生素暴露与较少的与抗生素相关的不良反应相关.
- 在普卡尔西群体中观察到较低全因死亡率的趋势.
结论:
- 在呼吸道感染中,对抗生素的测量是优化抗生素决策的重要工具.
- 实行以prokalcitonin为指导的治疗可以提高抗生素管理和提高患者的安全性.
- 进一步的研究可能会在更广泛的患者群体中确认死亡率的好处.
相关概念视频
05:12Murine Nasal Lavage Fluid Collection without Blood Contamination
1.7K
The present protocol describes a novel method for avoiding blood contamination in murine nasal lavage fluid (NLF). Since this method ensures the NLF collection without blood contamination, it allows for more accurate detections of immunological components and various respiratory...
1.7K
03:40Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
1.1K
OSTSS leads to pooled inflammatory mediators in the tear film, causing symptoms like epiphora and discomfort. Here, we present a case where therapeutic nasolacrimal lavage every 2 months resolved epiphora and itchiness, suggesting its efficacy as a therapeutic intervention for OSTSS. Additionally, we report subjective improvements in symptoms in 3 additional...
1.1K
04:35Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
880
Saline nasal lavage can be used to sample the canine nasal immune microenvironment. Because the approach is relatively non-invasive and does not disrupt the nasal tissues, it can be performed serially. Cells and proteins collected from the nasal lavage technique can be processed for various laboratory analyses.
880
08:47Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
2.9K
A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental...
2.9K
06:49Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
12.0K
Batrachochytrium dendrobatidis infection in amphibians can be eliminated using a reduced concentration (0.0025%) and shorter duration (five minute baths for six days) of itraconazole than is generally used. Less mortality and fewer negative side effects were observed using this modified treatment...
12.0K
07:15Intranasal Administration of CNS Therapeutics to Awake Mice
61.4K
A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic...
61.4K