人类肠道微生物组:从关联到调节
Thomas S B Schmidt1, Jeroen Raes2, Peer Bork3
1European Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany.
Cell
|March 10, 2018
概括
人类肠道微生物组的研究正在快速发展, 这份综述概述了将微生物组发现转化为针对人类的健康益处所需的重要研究.
科学领域:
- 微生物学
- 人类健康
- 胃肠病学
背景情况:
- 人们越来越了解肠道微生物组的复杂性.
- 将这些知识转化为实际的健康干预仍然是一个重大挑战.
研究的目的:
- 确定有效转化微生物组研究所需的研究类型.
- 引导开发针对宿主利益的微生物组调节.
主要方法:
- 对当前微生物组研究的文献综述.
- 分析研究设计的转化潜力.
主要成果:
- 需要特定的研究类型来弥合研究和应用之间的差距.
- 方法上的进步是实现目标微生物组效益的关键.
结论:
- 进一步的研究必须集中在转化研究上, 以利用肠道微生物组的治疗潜力.
- 开发有针对性的干预措施需要研究设计和执行的战略方法.
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