下肢动脉血栓形成后的癌症风险和预后
Jens Sundbøll1, Katalin Veres1, Erzsébet Horváth-Puhó1
1Department of Clinical Epidemiology, Aarhus University Hospital, Denmark.
Circulation
|March 16, 2018
概括
下肢动脉栓塞可能表明隐藏的癌症, 特别是肺癌. 这种情况也使常见癌症患者的生存率恶化,突出显示了其在癌症检测和预后方面的重要性.
科学领域:
- 血管医学
- 癌症学
- 流行病学
背景情况:
- 下肢动脉血栓与癌症风险/预后之间的联系尚未得到充分证实.
- 静脉血栓栓塞是已知的癌症症状,促使对动脉血栓的调查.
- 这项研究涉及下肢动脉血栓与癌症之间的未知关联.
研究的目的:
- 在被诊断为下肢动脉血栓的患者中调查癌症风险.
- 评估下肢动脉栓塞对癌症患者死亡率的预后影响.
- 为了确定下肢动脉血栓是否是隐性恶性瘤的早期标志物.
主要方法:
- 从1994年至2013年使用了全国性的丹麦医疗登记.
- 鉴定了首次下肢动脉栓塞的患者,并跟踪了随后的癌症诊断.
- 使用标准化发病率和匹配的队列来评估癌症风险和死亡率的影响.
主要成果:
- 在6600名下肢动脉瘤患者中观察到772种癌症.
- 癌症风险在前6个月显著增加 (SIR 3.28) 并且在12个月之后仍然很高 (SIR 1. 14).
- 肺癌和吸烟相关的癌症是最强烈的关联;几种常见癌症的动脉血栓增加死亡率.
结论:
- 下肢动脉血栓是隐性癌症的标志, 尤其是肺癌.
- 它是常见癌症患者死亡的不利预后因素.
- 早期发现下肢动脉血栓可能有助于识别未被诊断的恶性瘤.
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