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通过光亲和标记进行小分子相互作用映射,揭示了NSAIDs的结合点热点

Jinxu Gao1, Adelphe Mfuh1, Yuka Amako1

  • 1Department of Chemistry and Chemical Biology , Harvard University , 12 Oxford St. , Cambridge , Massachusetts 02138 , United States.

Journal of the American Chemical Society
|March 16, 2018
PubMed
概括

研究人员开发了一种新的方法,即通过光亲和标记 (SIM-PAL) 绘制小分子相互作用图. 这项技术确定了1000多种与非类固醇抗炎药物 (NSAID) 相互作用的蛋白质,揭示了直接结合部位和潜在的新疗法机制.

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