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相关概念视频

Spinal Cord01:26

Spinal Cord

2.0K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
2.0K
The Spinal Cord01:54

The Spinal Cord

31.9K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
31.9K
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

3.6K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
3.6K
Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

5.9K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
5.9K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

4.9K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
4.9K
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

1.9K
A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
1.9K

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相关实验视频

Updated: Feb 13, 2026

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
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Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

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用分池条形码对成长中的小鼠大脑和脊髓进行单细胞分析

Alexander B Rosenberg1, Charles M Roco2, Richard A Muscat3

  • 1Department of Electrical Engineering, University of Washington, Seattle, WA, USA. alex.b.rosenberg@gmail.com gseelig@uw.edu.

Science (New York, N.Y.)
|March 17, 2018
PubMed
概括
此摘要是机器生成的。

我们开发了基于分组结合的转录组测序 (SPLiT-seq) 来进行可扩展的单细胞RNA测序. 这种方法在发育中的小鼠大脑和脊髓中发现了100多种细胞类型.

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Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
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Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord

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Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples
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Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples

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相关实验视频

Last Updated: Feb 13, 2026

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing
06:38

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

Published on: October 12, 2018

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Assessment of Ultrastructural Neuroplasticity Parameters After In Utero Transduction of the Developing Mouse Brain and Spinal Cord
10:28

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Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples
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Extraction and Tissue Clearing Preparation of Mouse Brain-Spinal Cord Samples

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科学领域:

  • 分子生物学
  • 基因组学
  • 神经科学

背景情况:

  • 单细胞RNA测序 (scRNA-seq) 对于理解复杂的生物系统至关重要.
  • 现有的scRNA-seq方法在可扩展性和与固定样本的兼容性方面面临挑战.

研究的目的:

  • 开发一种可扩展和多用途的scRNA-seq方法来进行全面的细胞分析.
  • 在单细胞分辨率下分析发育中的小鼠中枢神经系统的转录组.

主要方法:

  • 使用组合条形编码开发基于分组结合的转录组序列 (SPLiT-seq).
  • 应用SPLiT-seq来分析156,049个单核转录组,这些转录组来自出生后的小鼠大脑和脊髓.
  • 使用伪时间分析来调查发育轨迹.

主要成果:

  • 根据基因表达模式识别了100多种不同的细胞类型.
  • 通过功能,区域特异性和分化阶段来表征细胞类型.
  • 揭示了转录程序驱动四个主要的发育系在早产后小鼠中枢神经系统.

结论:

  • SPLiT-seq可实现可扩展和高效的单细胞转录基因分析.
  • 提供早期出生后中枢神经系统发育的详细快照.
  • 提供其他复杂多细胞系统的综合分析方法.