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Updated: Feb 3, 2026

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
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多复合蛋白质动态分析揭示了控制蛋白质平衡的机制

Mikhail M Savitski1, Nico Zinn2, Maria Faelth-Savitski2

  • 1Cellzome GmbH, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany; Genome Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Cell
|March 20, 2018
PubMed
概括

我们开发了一种研究蛋白质降解和合成的新方法, mPDP揭示了细胞如何控制蛋白质水平,为生物过程和治疗策略提供了洞察力.

关键词:
HSP90 的情况一个 JQ这里是 PROTAC降解情况雌激素受体质谱学作用机制蛋白质周转率蛋白质稳定性

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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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No description available
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