人类序列数据的分析揭示了两种古老的丹尼索瓦混合物
Sharon R Browning1, Brian L Browning2, Ying Zhou1
1Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Cell
|March 20, 2018
概括
现代人类与尼安德特人和丹尼索瓦人等古老人种交配. 一种新方法揭示了欧亚和大洋洲群体中至少有两种不同的丹尼索瓦混杂事件.
科学领域:
- 人类的进化
- 种群遗传学
- 古代DNA分析
背景情况:
- 解剖学上的现代人类 (智人) 与古老的原始人 (包括尼安德特人和丹尼索瓦人) 交配.
- 尼安德特人和丹尼索瓦人的基因组测序使得人们能够识别当今人类中进化过的古老遗传物质.
- 在没有参考基因组的情况下检测入侵为识别更远的古老个体的细分提供了优势.
研究的目的:
- 应用一种新的无参考方法来检测古老的内进.
- 分析来自欧亚和大洋洲的全基因组序列的大数据集的内进模式.
- 在现代人类群体中调查丹尼索瓦人混合事件的数量和性质.
主要方法:
- 开发和应用一种无参考的古老内进检测方法.
- 对来自欧亚和大洋洲个体的5639个全基因组序列的分析.
- 对已识别的丹尼索瓦祖先组件与阿尔泰丹尼索瓦基因组进行比较分析.
主要成果:
- 在东亚,南亚和巴布亚新几内亚的群体中发现了丹尼索瓦人的祖先.
- 检测到的丹尼索瓦人的祖先至少由两个不同的组成部分组成.
- 这些成分与测序的阿尔泰丹尼索瓦人具有不同程度的相似性,表明多次混合事件.
结论:
- 至少有两例丹尼索瓦人与解剖学上现代人类混合.
- 这种混合涉及丹尼索瓦人群,与阿尔泰丹尼索瓦人有不同程度的亲属关系.
- 无参考方法有效地识别了古老的内进,包括不太亲密的古老人种.
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