在被占领的巴勒斯坦领土多次输血患者中的红细胞抗体:试点研究
Ahmad Yaseen1, Sa'd Suleiman1, Omar Abu Zenah1
1Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, West Bank, occupied Palestinian territory.
Lancet (London, England)
|March 20, 2018
概括
一项研究发现约旦河西岸多次输血患者中有15%的患者产生了艾洛抗体,主要是针对Rh和Kell血型. 这突显了对抗原匹配的输血的必要性,
科学领域:
- 血液学
- 免疫学
- 输血医学
背景情况:
- 红细胞输血对于治疗血和状细胞疾病至关重要.
- 然而,多次输血患者可能会受到免疫感染,导致输血反应.
- 艾洛抗体可能会使未来的输血和患者护理复杂化.
研究的目的:
- 在多次输血患者中确定alloantibodies的频率和类型.
- 评估约旦河西岸北部患者免疫发病率.
主要方法:
- 在约旦河西岸的三个thalassemia中心进行的试点研究.
- 使用标准实验室面板进行查和鉴定.
- 从131名患有甲血症或状细胞贫血的患者收集的数据.
主要成果:
- 在131名患者中,有15% (20名) 患有艾洛抗体.
- 大多数抗体是针对Rh血型系统的 (65%),包括抗D,抗E,抗Rh-C和抗c.
- 在 35% 的免疫患者中发现了抗凯尔抗体.
结论:
- 在该地区的多次输血患者中存在显著的非免疫性流行.
- 确定的主要类型是Rh和Kell血型系统抗体.
- 实施扩展红细胞表型和抗原匹配输血是缓解非免疫化的关键.
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