非抗生素药物对人类肠道细菌的广泛影响
Lisa Maier1, Mihaela Pruteanu1, Michael Kuhn2
1European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany.
Nature
|March 21, 2018
概括
许多常见的非抗生素药物会影响肠道细菌,可能导致抗生素耐药性. 研究人员选了1000多种药物,发现24%的药物抑制了细菌生长,突出了药物与微生物组相互作用的风险.
科学领域:
- 微生物学
- 药理学
- 基因组学
背景情况:
- 非抗生素药物越来越多地与肠道微生物组的改变有关.
- 这些药物对肠道细菌的全面影响在很大程度上仍未被描述.
研究的目的:
- 系统地选大量市场上的药物,以检测它们对肠道细菌的体外影响.
- 研究药物与微生物组相互作用与人类观察到的副作用之间的关系.
- 探索非抗生素药物使用与抗生素耐药性发展之间的潜在联系.
主要方法:
- 针对40种代表性肠道细菌菌株的1000多种药物的选.
- 在体外增长抑制试验.
- 与人类队列数据和已知的抗生素耐药性机制的相关性分析.
主要成果:
- 24%的针对人类的药物在体外抑制了至少一种细菌菌株的生长.
- 在影响细菌生长的药物中,抗精神病药物占比明显高.
- 对细菌观察到的药物作用与人类抗生素类似的副作用以及抗生素敏感性模式相关.
- 发现了抗生素和非抗生素药物之间共享耐药机制的证据.
结论:
- 通常处方的非抗生素药物可以显著影响肠道微生物组合和功能.
- 这些药物与微生物群的相互作用可能导致抗生素耐药性,需要进一步调查.
- 这些发现为了解药物的副作用,药物的重新用途以及更广泛的抗菌素耐药性提供了宝贵的资源.
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