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相关概念视频

DNA as a Genetic Template02:05

DNA as a Genetic Template

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA as a Genetic Template02:05

DNA as a Genetic Template

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Dehydration Synthesis01:15

Dehydration Synthesis

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Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
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Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

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Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. 
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Transfer RNA Synthesis02:36

Transfer RNA Synthesis

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One of the unique features of tRNA is the presence of modified bases. In some tRNAs, modified bases account for nearly 20% of the total bases in the molecule. Altogether, these unusual bases protect the tRNA from enzymatic degradation by RNases.
Each of these chemical modifications is carried by a specific enzyme, post-transcription. All of these enzymes have unique base and site-specificity. Methylation, the most common chemical modification, is carried by at least nine different enzymes, with...
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Lagging Strand Synthesis01:59

Lagging Strand Synthesis

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During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
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相关实验视频

Updated: Feb 13, 2026

A Salt-Templated Synthesis Method for Porous Platinum-based Macrobeams and Macrotubes
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A Salt-Templated Synthesis Method for Porous Platinum-based Macrobeams and Macrotubes

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有效的多组件活性模板合成卡特纳

James E M Lewis1, Florian Modicom1, Stephen M Goldup1

  • 1Chemistry , University of Southampton , Highfield , Southampton SO17 1BJ , United Kingdom.

Journal of the American Chemical Society
|March 21, 2018
PubMed
概括

这项研究引入了有效的活性模板合成 [2]catenanes. 该方法通过点击化学实现了机械键形成,简化了复杂的连锁结构的创建.

科学领域:

  • 超分子化学
  • 有机合成

背景情况:

  • 卡特纳是具有独特拓性质的机械互锁分子.
  • 之前的合成方法通常需要复杂的程序或低产量.

研究的目的:

  • 开发一种简单且高产的活性模板合成 [2]链.
  • 为了证明该方法对各种前体组合的多功能性.

主要方法:

  • 使用积极的模板策略来形成机械纽带.
  • 采用阿齐德和基函数组之间的点击化学.
  • 调查单个前宏循环和共同宏循环的方法.

主要成果:

  • 在合成 [2]catenanes中获得高产量.
  • 使用 bis-alkyne 和 bis-azide 共同体证明了成功的宏环化.
  • 在循环化之前导致寡合的短/亚成分的适用性被证明.

结论:

  • 描述的方法提供了一个简单而有效的途径 [2]链.
  • 活性模板方法可适应于高分子化学中的多种合成策略.

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