通过顺序异构化/交叉合反应进行高替代的多触媒立体选择性合成
1Department of Organic Chemistry , University of Geneva , 30 quai Ernest Ansermet , 1211 Geneva , Switzerland.
Journal of the American Chemical Society
|March 22, 2018
概括
这项研究引入了两种新型的多催化序列,用于从基乙烯中立体选择性地合成高度替代的基. 这些方法有效地结合了异构化和交叉合,为复杂的基结构提供了多功能途径.
科学领域:
- 有机化学
- 催化剂
- 合成方法
背景情况:
- 高度替代的立体选择性合成仍然是有机化学的一个重大挑战.
- 开发有效的催化方法来构建复杂的C=C键对于获得新型分子架构至关重要.
研究的目的:
- 开发两种互补的多催化序列异构化/交叉合策略,用于高度替代的立体选择性制备.
- 探索这些方法与各种功能组和基替代模式的兼容性.
- 建立对性烯酸化合物具有选择性的变体.
主要方法:
- 使用阴离子催化剂对基乙醇进行立体选择性异构.
- 使用催化剂对现场生成的甲基乙烯和格林纳德试剂进行交叉合.
- 开发了具有远程C=C键的甲基乙烯的补充/催化序列.
主要成果:
- 在新形成的C=C键上具有高控制度的高度替代的立体选择性合成.
- 与敏感的功能组和多种基替代模式的兼容性得到证明.
- 通过使用性预催化剂建立了高度选择性的[Ir/Ni]序列.
- [Pd/Ni] 序列产生了具有较低立体控制的基,但使C(sp2) -C(sp2) 和C(sp2) -C(sp3) 键构造成为可能.
结论:
- 开发的多催化序列为有价值的,高度替代的提供了高效和多功能途径.
- 这些方法提供了难以使用传统方法合成的复杂分子.
- 能够构建C(sp2) -C(sp2) 和C(sp2) -C(sp3) 键,扩大了这些催化系统的合成效用.
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