通过双臂神经元编码危险
Carlos A Campos1, Anna J Bowen1, Carolyn W Roman1
1Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
Nature
|March 22, 2018
概括
甲核中的基因相关的神经元 (CGRPPBN神经元) 表示威胁. 这些神经元被危险激活,并在食期间被抑制,
科学领域:
- 神经科学
- 行为生物学
- 感官生理学
背景情况:
- 需要对各种威胁做出适当的反应.
- 基因相关 (CGRP) 神经元在核 (PBN) 中参与处理和恐惧行为.
- 这些不同过程的精确编码机制由CGRPPBN神经元仍然不完全理解.
研究的目的:
- 研究CGRPPBN神经元在编码与威胁和养行为相关的感官信号中的作用.
- 确定CGRPPBN神经元如何促进适应性行为状态.
主要方法:
- 在小鼠中单个CGRPPBN神经元的体内成像.
- 记录神经元活动对有害皮肤和内脏刺激的反应.
- 评估神经元在食,腹以及对新食物和条件恐惧刺激的反应.
- 评估CGRPPBN神经元沉默对食物恐惧和条件恐惧的行为影响.
主要成果:
- 大多数CGRPPBN神经元被有害刺激 (皮肤和内脏) 激活.
- 这些神经元在食期间被抑制,但在腹期间被激活,这表明它们在防止过度进食方面发挥了作用.
- CGRPPBN神经元对新的食物消费和与负面体验相关的听觉线索做出反应.
- 沉默CGRPPBN神经元可以减少食物恐惧症和条件恐惧反应.
结论:
- CGRPPBN神经元对于传感主要危险信号至关重要.
- 这些神经元在促进情感行为状态方面发挥着重要作用,
- CGRPPBN神经元整合感官信息来编排适应性生存行为.
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