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使用检查点封锁的癌症免疫疗法

Antoni Ribas1, Jedd D Wolchok2,3

  • 1Department of Medicine, Division of Hematology-Oncology; Department of Surgery, Division of Surgical Oncology; and Department of Molecular and Medical Pharmacology, Jonsson Comprehensive Cancer Center and Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, Los Angeles, CA 90095, USA. aribas@mednet.ucla.edu wolchokj@mskcc.org.

Science (New York, N.Y.)
|March 24, 2018
PubMed
概括

免疫检查点抑制剂如CTLA-4和PD-1疗法提供持久的癌症反应. 然而,可以通过抗原呈现和干扰素-γ通路变化出现获得的耐药性,需要新的组合策略.

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