内皮NAD+-H2S信号网络的损伤是血管衰老的可逆原因
Abhirup Das1, George X Huang2, Michael S Bonkowski3
1Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia; Paul F. Glenn Center for Science of Aging Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Cell
|March 24, 2018
概括
尼古丁胺单核酸 (NMN) 通过激活SIRT1增加毛细血管密度,从而提高老鼠的血液流动和耐力. 运动和硫化进一步增强了这些抗衰老作用.
科学领域:
- 老龄化研究
- 血管生物学
- 代谢途径
背景情况:
- 毛细血管密度和血液流量随着年龄的增长而下降,导致死亡率和发病率.
- 包括尼古丁胺 mononucleotide (NMN) 在内的 NAD+ 前体可以通过激活 sirtuin deacylases (SIRT) 来逆转一些衰老方面.
- 内皮细胞中的Sirtuin 1 (SIRT1) 对于介导肌细胞的亲血管信号至关重要.
研究的目的:
- 研究SIRT1在与年龄相关的血液流量和毛细血管密度下降中的作用.
- 确定NMN补充剂在改善老年小鼠血管功能和耐力方面的有效性.
- 探索运动和硫化 (H2S) 与NMN的协同作用.
主要方法:
- 给老年小鼠使用NMN.
- 血液流动和毛细血管密度的评估.
- 对耐力性能进行评估.
- 研究SIRT1激活和H2S水平的作用.
主要成果:
- 在老年小鼠中,NMN治疗改善了血液流动和耐力.
- 这些改善与SIRT1依赖的毛细血管密度增加有关.
- 运动和增加的H2S水平增加了NMN的有益作用.
- H2S被确定为饮食限制模仿剂和内皮NAD+水平的调节剂.
结论:
- 通过NMN激活SIRT1可以抵消与年龄相关的血管功能下降.
- NMN 具有改善器官血液流动,提高人类表现和促进老年人的运动的潜力.
- 运动和H2S等联合干预措施可能进一步增强NAD+增强剂的抗衰老效果.
相关概念视频
03:24Seedless Vascular Plants
67.7K
Seedless Vascular Plants Were the First Tall Plants on Earth
67.7K
02:26Protein Networks
4.6K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.6K
02:26Protein Networks
2.9K
2.9K
01:21Paracrine Signaling
59.7K
Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
59.7K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
01:26Aging
801
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
801