在扩散控制中的深层组织特异性是癌症驱动因素和无质形成模式的基础
Laura Magill Sack1, Teresa Davoli1, Mamie Z Li1
1Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Cell
|March 27, 2018
概括
科学家发现了调节癌细胞增殖的基因,发现大多数是特定于组织的. 这些扩散驱动因素与瘤的拷贝数量变化有关, 揭示了癌症遗传学和动脉积分的洞察力.
科学领域:
- 基因组学
- 癌症生物学
- 分子遗传学
背景情况:
- 癌症的特征是无法控制的细胞增殖.
- 鉴定致癌驱动因素,特别是通过基因剂量作用的驱动因素,仍然是一个挑战.
- 基因组学有详细的癌症基因组结构,
研究的目的:
- 在不同的人类细胞类型中识别调节癌细胞增殖的基因.
- 研究瘤中的增殖调节剂和体质拷贝数变化 (SCNA) 之间的关系.
- 了解SCNA和癌症驱动器选择的基因网络架构.
主要方法:
- 人类开放阅读框架 (ORF) 的模块化条形码库的构建.
- 对ORF库进行高通量选,以识别多种细胞类型中的增殖调节剂.
- 在相应瘤中的SCNA数据中对基因丰富的分析.
- 在体内查以验证发现.
主要成果:
- 大约10%的基因被确定为增殖调节剂.
- 大多数已识别的增殖调节剂具有高组织特异性.
- 在相关瘤中,增殖驱动因素显著丰富SCNAs.
- 与SCNA相关的驱动因素有助于预测瘤中的血管积分模式.
- 147个放大和107个删除的基因被确定为潜在的SCNA相关驱动因素.
结论:
- 组织特异性遗传网络影响SCNA和不同癌症类型的驱动选择.
- 根据具体情况,SCNA与特定的扩散驱动因素联系在一起.
- 这项研究显著扩大了SCNA相关的癌症驱动因素的目录,并提供了对瘤形结构的见解.
相关概念视频
Abnormal Proliferation
5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K
Fixed Action Patterns
17.7K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.7K
Patterns of Fever
4.0K
Before understanding the types and patterns of fever, it is essential to know its phases.
4.0K
Cells Coordinate Growth and Proliferation
5.1K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
Specific Heat
67.6K
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.6K
Control System Problem
443
In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
443


