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相关概念视频

Structural Protein Function01:56

Structural Protein Function

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
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Structural Protein Function01:56

Structural Protein Function

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Mechanical Protein Functions01:58

Mechanical Protein Functions

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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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Random or indeterminate errors originate from various uncontrollable variables, such as variations in environmental conditions, instrument imperfections, or the inherent variability of the phenomena being measured. Usually, these errors cannot be predicted, estimated, or characterized because their direction and magnitude often vary in magnitude and direction even during consecutive measurements. As a result, they are difficult to eliminate. However, the aggregate effect of these errors can be...
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Random Variables01:09

Random Variables

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A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
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The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
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相关实验视频

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Transient Expression of Foreign Genes in Insect Cells sf9 for Protein Functional Assay
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随机异质聚合物在外来环境中保持蛋白质功能

Brian Panganiban1, Baofu Qiao2, Tao Jiang1

  • 1Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|March 29, 2018
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概括

科学家们创造了新型合成聚合物, 这一突破可以开发先进的生物材料,例如用于毒素生物修复的含酶塑料.

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科学领域:

  • 生物材料科学
  • 聚合物化学
  • 生物技术

背景情况:

  • 将活性蛋白纳入合成聚合物提供了新生物材料的潜力.
  • 蛋白质通常在标准的聚合物加工条件下不起作用.
  • 模仿内在无序的蛋白质是克服这一挑战的关键.

研究的目的:

  • 设计能够在非原生环境中溶解和稳定蛋白质的合成异质聚合物.
  • 为基于蛋白质的应用创造一种新的生物系统与合成材料的接口策略.

主要方法:

  • 分析蛋白质序列趋势和表面化学模式.
  • 设计具有优化组成和统计单体分布的四个单体随机异质聚合物.
  • 在膜蛋白和含酶塑料的无细胞合成中应用异聚合物.

主要成果:

  • 开发出模仿内在无序蛋白质的异质聚合物,使蛋白质在非原生条件下稳定.
  • 在无细胞合成的膜蛋白中实现了适当的蛋白质折叠.
  • 使用含有酶的塑料证明了毒素的成功生物修复.

结论:

  • 控制异质聚合物中的统计单体分布是一种可行的蛋白质稳定策略.
  • 这种方法使得基于蛋白质的功能生物材料可以用于各种应用.
  • 这些发现为生物功能与合成材料的交互开辟了新的途径.