从视觉皮层的单细胞投影的逻辑
Yunyun Han1,2,3, Justus M Kebschull4,5, Robert A A Campbell3
1Department of Neurobiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Nature
|March 29, 2018
概括
单个神经元在老鼠大脑中的项目到多个区域, 挑战单个目标神经元通信的想法. 这一发现揭示了大脑区域之间复杂的信息共享,
科学领域:
- 神经科学
- 系统神经科学
- 计算神经科学
背景情况:
- 新皮层通信依赖于轴突投射,但个体神经元投射模式在很大程度上是未知的.
- 了解信息传输需要对神经元目标进行系统的描述.
研究的目的:
- 系统地绘制小鼠主要视觉皮层中的单个神经元的投影模式.
- 确定单个神经元是否向单个或多个皮质和皮质下区域投射.
主要方法:
- 使用基于全脑光的轴突追踪.
- 在591个单个神经元中使用了基因条码神经元的高通量DNA测序 (MAPseq).
主要成果:
- 发现高度多样化和分歧的投影, 针对至少18个皮质和皮质下区域.
- 发现大多数神经元以非随机的组合投射到多个皮质区域,
- 证明信息传输不是一个"一个神经元一个目标区域"的系统.
结论:
- 个体皮质神经元在目标区域的子集之间共享信号.
- 神经元信号同时有助于多个功能途径,表明一个复杂的信息共享模型.
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