通过不对称的布伦斯特酸催化剂激活烯酸
Nobuya Tsuji1, Jennifer L Kennemur1, Thomas Buyck1
1Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
概括
化学家开发了强烈的性布伦斯特德酸来催化不对称的反应. 这种新方法有效地从简单的烯酸中合成生物活性四氨酸,克服了主要的合成障碍.
科学领域:
- 有机化学
- 不对称的催化
- 绿色化学
背景情况:
- 传统的不对称合成使用过渡金属催化剂.
- 酶通过布伦斯特德酸位激活烯酸,形成天然产品合成的碳酸盐.
- 用奇拉布伦斯特德酸激活简单的烯酸进行不对称的催化仍然具有挑战性.
研究的目的:
- 开发一种对不对称的分子内氧化无偏烯的催化系统.
- 模仿使用合成性布伦斯特德酸的酶激活.
- 提供快速获取有价值的1,1-非替代四.
主要方法:
- 使用封闭和强的布伦斯特德酸.
- 开发了一种催化不对称的分子内氧化方法.
- 应用该方法合成生物活性化合物.
主要成果:
- 实现了无偏向的氨酸的催化不对称的分子内氧化.
- 证明了 1,1-非替代四氨酸的快速合成.
- 成功合成了 (-) - 博伊维尼安尼A.
结论:
- 封闭的强布伦斯特德酸是有效的催化剂.
- 开发的方法提供了一条新的途径,以致能丰富的四素.
- 这种方法可以获得复杂的天然产品和药物中间体.
相关概念视频
Catalysis
30.7K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
30.7K
Brønsted-Lowry Acids and Bases
25.1K
In 1923, the Brønsted–Lowry definition of acids and bases was proposed by Johannes Brønsted and Thomas Lowry. According to this theory, a Brønsted acid is defined as a species that donates a proton in a chemical reaction and gets converted to its conjugate base. A Brønsted base is defined as a species that accepts a proton in a chemical reaction and gets converted into its conjugate acid. These transfers of protons are caused by the displacement of electrons in these reactions, which is...
25.1K
Lewis Acids and Bases
48.5K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.5K
Bronsted-Lowry Acids and Bases
105.9K
The acid-base reaction class has been studied for quite some time. In 1680, Robert Boyle reported traits of acid solutions that included their ability to dissolve many substances, to change the colors of certain natural dyes, and to lose these traits after coming in contact with alkali (base) solutions. In the eighteenth century, it was recognized that acids have a sour taste, react with limestone to liberate a gaseous substance (now known to be CO2), and interact with alkalis to form neutral...
105.9K
Weak Acid Solutions
43.3K
Few compounds act as strong acids. A far greater number of compounds behave as weak acids and only partially react with water, leaving a large majority of dissolved molecules in their original form and generating a relatively small amount of hydronium ions. Weak acids are commonly encountered in nature, being the substances partly responsible for the tangy taste of citrus fruits, the stinging sensation of insect bites, and the unpleasant smells associated with body odor. A familiar example of a...
43.3K
Rotation of Asymmetric Top
1.6K
By definition, a spherically symmetric body has the same moment of inertia about any axis passing through its center of mass. This situation changes if there is no spherical symmetry. Since most rigid bodies are not spherically symmetric, these require special treatment.
The relationship between the angular momentum of any rigid body and its angular velocity, both of which are vectors, involves the moment of inertia. The moment of inertia is a scalar quantity only for spherically symmetric...
The relationship between the angular momentum of any rigid body and its angular velocity, both of which are vectors, involves the moment of inertia. The moment of inertia is a scalar quantity only for spherically symmetric...
1.6K


