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Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
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ISRIB的结合揭示了核酸交换因子eIF2B中的一个调节部位

Alisa F Zyryanova1, Félix Weis2,3,4,5, Alexandre Faille2,3,4

  • 1Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. az310@cam.ac.uk ajw1000@cam.ac.uk dr360@medschl.cam.ac.uk.

Science (New York, N.Y.)
|March 31, 2018
PubMed
概括

综合应激反应 (ISR) 抑制剂ISRIB与eIF2B复合体结合,揭示了一个关键的调节部位. 这种结构洞察力解释了ISRIB如何调节翻译,并为神经退行性疾病提供了潜在的治疗点.

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