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Updated: Feb 12, 2026

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通过BCL11A直接抑制,控制胎儿对成人血红蛋白的切换

Nan Liu1, Victoria V Hargreaves1, Qian Zhu2

  • 1Cancer and Blood Disorders Center, Dana Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Cell
|April 3, 2018
PubMed
概括

BCL11A直接抑制胎儿血红蛋白 (HbF) 基因表达,导致转换为成人血红蛋白 (HbA). 这种机制涉及γ-环球蛋白促进体中的特定DNA基因,对于调节环球蛋白基因切换至关重要.

关键词:
其他类型切割和运行对DNA进行结合数字基因足迹基因编辑血红蛋白蛋白质结合微阵列镇压指

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