代谢酶 PFKFB4 激活转录协活性剂 SRC-3 驱动乳腺癌

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Subhamoy Dasgupta1,2, Kimal Rajapakshe3, Bokai Zhu3

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. subhamoy.dasgupta@roswellpark.org.

Nature
|April 5, 2018
PubMed
概括

代谢酶PFKFB4激活致癌的SRC-3,将糖代谢与转录性变化联系起来,这些变化推动了侵袭性乳腺癌的生长和转移. 这一发现揭示了转移性瘤的新疗法.

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