一个简要的方法对Anthraquinone-Xanthone异构体
Stephen D Holmbo1, Sergey V Pronin1
1Department of Chemistry , University of California , Irvine , California 92697-2025 , United States.
Journal of the American Chemical Society
|April 6, 2018
概括
研究人员开发了一种新型合成途径,以获得 antraquinone-xanthone异构体. 这种方法有效地构建了五环核,使得Acremoxanthone A的合成成为可能.
科学领域:
- 有机化学
- 合成化学
- 异环化学
背景情况:
- 人类 - 桑异构体是具有潜在生物活性的复杂天然产品.
- 需要有效的合成策略来访问这些有价值的分子架构.
研究的目的:
- 开发一种新且高效的合成方法,用于构建基异构体.
- 通过Acremoxanthone A的合成来证明开发方法的实用性.
主要方法:
- 乙醇以太的分子内氧化化,用于环烯组合.
- 对于双环[3.2.2]非基基基因构造的豪泽-克劳斯无效-阿尔多尔反应序列.
- 从商用材料开始的多步合成.
主要成果:
- 已经确定了一条有效的通向五环原子核的途径.
- 在10个步骤中成功合成了Acremoxanthone A.
- 合成策略在访问复杂的异环系统方面被证明有效.
结论:
- 描述的合成方法提供了一种可行的通道,以获得 antraquinone-xanthone 异构体.
- 这种方法是有效的,适用于合成像Acremoxanthone A这样的天然产品.
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