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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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压力颗粒组装扰乱了核细胞质运输

Ke Zhang1, J Gavin Daigle1, Kathleen M Cunningham2

  • 1Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Brain Science Institute, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

Cell
|April 10, 2018
PubMed
概括

细胞压力通过形成压力颗粒来破坏神经退行性疾病中的核细胞质运输. 例如通过向ATAXIN-2来抑制这些颗粒,可以防止传输缺陷和神经退行.

关键词:
美国美国核细胞质运输压力颗粒

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