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Triplet Fusion Upconversion Nanocapsule Synthesis
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在水稳定的金属有机框架中进行3D远程三重迁移,用于基于上转换的超低功率的生物成像
Jihye Park1, Ming Xu2, Fuyou Li2
1Department of Chemistry , Texas A&M University , College Station , Texas 77843-3255 , United States.
Journal of the American Chemical Society
|April 11, 2018
概括
研究人员开发了一种金属有机框架 (MOF),用于水性环境中高效的三倍-三倍灭绝上转换 (TTA-UC). 这种生物相容的纳米平台可实现高信号比噪声的低功耗体内成像.
科学领域:
- 材料科学
- 摄影化学
- 纳米技术
背景情况:
- 三倍-三倍灭绝上转换 (TTA-UC) 有效地收集低能光子,用于太阳能电池和生物成像等应用.
- 传统的TTA-UC系统在水中存在局限性,由于不兼容性和低效率,阻碍其在低功耗生物应用中使用.
研究的目的:
- 开发一个生物相容的纳米平台,用于在水中有效的TTA-UC.
- 使用TTA-UC进行低功率体内成像.
- 克服传统TTA-UC系统在生物应用中的局限性.
主要方法:
- 使用氨酸敏感剂和基于氨酸的Zr-MOF合成了一种金属有机框架 (MOF).
- MOF结构促进了长距离的三维扩散 (1.6μm) 以有效地在水中进行能量迁移.
- 敏感剂与消灭剂的比率被调整为优化TTA-UC效率.
主要成果:
- 在低激发功率密度下,MOF平台在水溶液中展示了高效的TTA-UC.
- 通过调整敏感剂/消灭剂比率来实现TTA-UC效率的优化.
- 在活小鼠中,成功的低功率淋巴结成像得到了高SNR (> 30在5mW cm-2).
结论:
- 开发的MOF作为一个有前途的生物相容纳米平台,用于在水环境中高效的TTA-UC.
- 这种方法可以实现高性能,低功耗的体内成像,扩大TTA-UC在生物医学应用中的实用性.
- 这些发现突显了MOF在生物系统中先进的光物理过程中的潜力.
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